There is your first mistake, you need to uncheck that box because obviously the game would not execute because you just prevented it by checking the box....I tried setting splintercell4 to "do not start exe when profile is launched" and manually starting the game after activating the profile but again nothing...
The second thing you need to do is launch PGP as Administrator because windows seems to be blocking the signals from PGP executing the kb keys and mouse.


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