Here is a Profile for Unreal II for use with the XBOX360 Controller.
to respond to options within the game dialog you need to use the left and right shoulder buttons. you will notice in the game thad when presented with more than one option during a conversation the different choices will be numbered.
to select an option simply press the left shoulder button the same number of times as is displayed for that choice then press the right shoulder button to execute the dialog option. this is also a nother way to change your weapon when not in a dialog screen. you have to be standing still for this to work though.
To Quicksave simply hold the back button for 1/2 a second. this is so you dont accedently quicksave someplace you dont want to.